Saturday, November 25, 2023

Does Breast Cancer Spread To Thyroid

What About Other Treatments That I Hear About

Mayo Clinic explains thyroid cancer

When you have cancer you might hear about other ways to treat the cancer or treat your symptoms. These may not always be standard medical treatments. These treatments may be vitamins, herbs, special diets, and other things. You may wonder about these treatments.

Some of these are known to help, but many have not been tested. Some have been shown not to help. A few have even been found to be harmful. Talk to your doctor about anything youre thinking about using, whether its a vitamin, a diet, or anything else.

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How Is Papillary Thyroid Cancer Treated

Treatments for papillary thyroid cancer depend on the tumor size and whether the cancer has spread .

Surgery is the most common treatment for PTC. Depending on the tumors size and location, your surgeon may remove part of your thyroid gland or all of your gland . If you have cancer present in the lymph nodes of your neck, your surgeon may remove the affected lymph nodes at the time of the initial thyroid surgery or as a second procedure.

If you have a total thyroidectomy, youll need to take thyroid hormone replacement medication for the rest of your life.

Additional treatments for PTC include:

  • Radioiodine therapy: Thyroid cells and papillary thyroid cancer cells absorb iodine, a mineral found in some food. Because of this, healthcare providers sometimes use a radioactive form of iodine to destroy all remaining normal thyroid tissue and potentially destroy residual cancerous thyroid tissue after a thyroidectomy.
  • Radiation therapy: Radiation kills cancer cells and stops them from growing. External radiation therapy uses a machine to deliver strong beams of energy directly to the tumor site. Internal radiation therapy involves placing radioactive seeds in or around the tumor.
  • Chemotherapy: Intravenous or oral chemotherapy drugs kill cancer cells and stop cancer growth. Very few people diagnosed with thyroid cancer will ever need chemotherapy.

How Will I Know If My Breast Cancer Spreads

Your doctor will use specific kinds of tests to find out if your cancer has gone to other places in your body. First, your doctor will want to know how youâre feeling. They will ask you about any symptoms youâre having and your overall health. They might also look at the size of your tumor and check your lymph nodes.

After that, the doctor may give you:

Blood tests. They look for signs of anything abnormal thatâs happening in your body. For example, results from a liver function test can let your doctor know that breast cancer may have gone to your liver. High levels of some substances in your blood hint that the cancer has spread to your bones.

Imaging scans. These tests make detailed pictures of the inside of your body. They help your doctor pinpoint any cancer spread. These tests include:

Biopsy. Your doctor removes a small amount of tissue from your body and looks at it under a microscope to see if there are any cancer cells in it.

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Other Signs And Symptoms

Other, more rare or unusual signs of medullary thyroid cancer that you should be aware of include:

  • Severe diarrhea. This is a very rare symptom sometimes found in people with advanced medullary thyroid cancer. The tumor produces high levels of calcitonin, a hormone that may cause severe diarrhea.
  • Cushing syndrome. In rare cases, adrenal tumors can cause Cushing syndrome, a condition that arises when a tumor secretes hormones that the thyroid wouldnt normal create. Cushing syndrome associated with medullary thyroid cancer is uncommon. The syndrome is more commonly caused by the pituitary gland overproducing adrenocorticotropic hormone , or by taking oral corticosteroid medication.
  • Facial flushing. A red face, neck, or chest paired with warm or burning sensations can be a sign of many conditions. Tumors or other abnormal growths can overproduce hormones, triggering flushing. The symptom can also be a response to certain drugs, foods, alcohol, or menopause.
  • Bone pain. People with medullary thyroid cancer may have bone pain if the cancer has spread to form bone lesions.
  • Lethargy. Many people with advanced cancer may feel physically, emotionally, or mentally tired. The causes of fatigue during cancer are complex and not well understood.
  • Weight loss. Unusual weight loss is a symptom of advanced medullary thyroid cancer that has spread beyond the thyroid into other organs.

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Case Report And Review Of Literature: Thyroid Metastases From Breast Carcinoma

Does Thyroid Cancer Spread To Breast
  • 1Department of Thyroid & Parathyroid Surgery Center, West China Hospital, Sichuan University, Chengdu, China
  • 2West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China
  • 3Department of Sonography, West China Hospital, Sichuan University, Chengdu, China
  • 4Department of Pathology, West China Hospital, Sichuan University, Chengdu, China

Rationale: The thyroid is a rare site for distant metastases from breast carcinoma. The incidence of thyroid metastases in fine needle aspiration biopsy was less than 0.2%.

Patient concerns: We report a case of 54-year-old woman with a history of breast carcinoma presented with diffuse scattered microcalcifications in thyroid and enlarged bilateral cervical lymph nodes detected on ultrasound . Physical examination of the patient revealed firm and enlarged thyroid lobes.

Diagnoses: FNAB and immunohistochemistry of the thyroid lesion confirmed the thyroid metastases from breast cancer.

Interventions and Outcomes: Due to the comorbidities of breast carcinoma metastases to the right axillary, cervical lymph nodes and left chest wall, the patient received chemotherapy. After a follow-up of 19 months, the patient was alive without any new distant metastases.

Lessons: Our case highlights that thyroid metastases should be considered in a patient combined with thyroid lesions and a history of breast carcinoma. IHC played an important role in differentiating thyroid metastases from primary thyroid cancer.

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Differentiated Thyroid Cancer In Patients Younger Than 55

Younger people have a low likelihood of dying from differentiated thyroid cancer. The TNM stage groupings for these cancers take this fact into account. So, all people younger than 55 years with these cancers are stage I if they have no distant spread and stage II if they have distant spread. This table includes patients 55 or older as well as younger than 55.

AJCC Stage

Any N

The cancer is any size and might or might not have spread to nearby lymph nodes .

It has spread to other parts of the body, such as distant lymph nodes, internal organs, bones, etc. .

* The following additional categories are not listed on the table above:

  • TX: Main tumor cannot be assessed due to lack of information.
  • T0: No evidence of a primary tumor. The N categories are described in the table above, except for:
  • NX: Regional lymph nodes cannot be assessed due to lack of information.

Calculating Risk Based On Tumor Size

Memorial Sloan Kettering Cancer Center provides a Breast Cancer Nomogram through which you can predict the likelihood that a breast cancer has spread to axillary lymph nodes based on tumor size .

To complete this estimate, you are asked to agree to the conditions, and understand that it is only an estimate.

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What Are The Symptoms Of Thyroid Cancer

The earliest sign of thyroid cancer is typically a lump or nodule at the base of the neck. You may be able to see and feel this lump yourself, or your physician may notice it during a routine checkup. Other symptoms of thyroid cancer that may be present early on before it has metastasized include:

  • Changes in your voice or constant hoarseness
  • Pain or soreness in the front of the neck
  • A persistent cough
  • Trouble swallowing
  • Difficulty breathing

When thyroid cancer advances and metastasizes to distant areas of the body, some additional symptoms may be present. Metastatic thyroid cancer symptoms include:

Multifocal Metastatic Breast Carcinoma To The Thyroid Gland Histologically Mimicking C Cell Lesions

My Thyroid Cancer journey pt. 3 || Cancer spread? Thyroid function? Post surgery update!

Stacey K. Mardekian

1Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107, USA

2Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA

3Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA


The thyroid gland is an uncommon site of metastatic disease. Renal cell carcinoma is the most common primary source, while metastasis from breast carcinoma is very rare. However, given that thyroid nodules are more common in women, and women with a history of breast cancer are at higher risk of developing thyroid cancer, the possibility of metastatic breast carcinoma must be considered when evaluating a thyroid nodule. We present the case of a 67-year-old woman who presented with dysphonia and dysphagia secondary to multinodular goiter and was found to have multifocal metastatic breast carcinoma in her surgical resection specimen. The histologic appearance focally mimicked C cell hyperplasia and medullary thyroid carcinoma, so immunohistochemistry was critical for establishing the diagnosis. Metastasis to the thyroid should always be included in the differential diagnosis for a thyroid nodule in a patient with a history of previous malignancy.

1. Introduction

Conflicts of Interest

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How Is Papillary Thyroid Cancer Diagnosed

Papillary thyroid cancer usually presents as a lump or nodule on your thyroid gland. You may notice it, or your healthcare provider may discover it during a routine neck examination. Sometimes, the nodule is discovered incidentally by imaging tests you get for other medical reasons.

Your healthcare provider will likely order the following tests to help diagnose PTC:

  • Imaging tests: Your provider may order imaging tests to identify the nodule on your thyroid. These tests might include thyroid ultrasound, CT scan and/or magnetic resonance imaging .
  • Fine needle aspiration : Your provider will likely want to take a small tissue sample, called a biopsy, from the nodule on your thyroid using a very thin needle. A pathologist will look at the tissue under a microscope to see if there are cancer cells and, if so, what type of thyroid cancer it is.

Your healthcare provider may also recommend genetic counseling to see if you have a genetic condition that may have caused PTC and may cause other types of tumors.

Other Less Common Areas Breast Cancer May Spread To

Breast cancer metastasis isnt just limited to the sites weve listed above. Breast cancer can also spread to other areas of the body, although this is much less common. Some examples

Some symptoms may not be caused by the cancer itself, but by the treatment that youre undergoing. If youre experiencing any of these symptoms, speak with your doctor. They may be able to recommend a therapy to alleviate some symptoms.

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What Is The Epidemiologic Evidence Of The Relationship Between Breast And Thyroid Cancer

In the past few years alone, population studies in Asia, Europe, and the United States reveal increased incidence of breast cancer among women previously diagnosed with thyroid cancer . Of note, aggressive follicular thyroid cancer is detected in patients with a history of breast cancer more often than the more common papillary thyroid cancer . Furthermore, and importantly for determining etiology, nonmalignant thyroid nodules are more common in women with breast cancer than those without breast tumors . There is an increased risk of developing thyroid cancer following breast cancer . Women with prior benign breast disease also are reported to be at a greater risk of thyroid cancer . The increased risk of thyroid cancer following breast cancer and breast cancer following thyroid cancer is reported in both women and men . Women with breast cancer are 2-fold more likely to develop future thyroid cancer and women with thyroid cancer have a 67% greater chance of developing breast cancer than the general population. These recent studies are summarized in . Importantly, the metachronous relationship was evaluated in nations with widespread cancer screening and nations where screening is becoming more common. In particular, Zhang and colleagues evaluated patients with cancer between 2001 and 2010 in China, which corresponded with investments into cancer registries .

Where Does Breast Cancer Spread

Can Thyroid Cancer Spread To Salivary Glands

When cancer cells in your breast spread to other parts of your body, itâs called metastatic breast cancer. Your doctor might refer to it as stage IV or advanced cancer. The cells can go anywhere, but there are a few places where they typically appear.

No matter where breast cancer spreads, there are treatments that can manage your condition and help you continue to live your life.

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What Are Biopsies And Why Do I Need One

Biopsies are the most common way that doctors diagnose cancer. During a biopsy, a doctor takes a small piece of tissue, called a sample, from a suspected tumor or area of concern. Then, a pathologist looks at it under a microscope to make a diagnosis. A pathologist is a doctor who specializes in interpreting laboratory tests and evaluating cells, tissues, and organs to diagnose disease, including cancer.

There are many different techniques for collecting a biopsy. For example, in a fine needle aspiration biopsy, the doctor inserts a needle attached to a syringe into the suspicious area to collect a small amount of tissue for diagnosis. In an excisional biopsy, the doctor removes the entire suspicious mass for examination.

Properly performed, biopsies often provide essential information to help diagnose, stage, and inform clinical decision-making for patients with suspected or known cancer. Jeffrey E. Gershenwald, MD, FACS, professor in the Department of Surgical Oncology in the Division of Surgery at the University of Texas MD Anderson Cancer Center in Houston, Texas, and Cancer.Net Editorial Board member.

How Is The Stage Determined

The staging system most often used for thyroid cancer is the AJCC TNM system, which is based on 3 key pieces of information:

  • The extent of the tumor : How large is the cancer? Has it grown into nearby structures?
  • The spread to nearby lymph nodes : Has the cancer spread to nearby lymph nodes?
  • The spread to distant sites : Has the cancer spread to the distant organs such as the lungs or liver?

The systems described below are the most recent AJCC systems effective January 2018 and applies to differentiated, anaplastic and medullary thyroid cancers.

Numbers or letters after T, N, and M provide more details about each of these factors. Higher numbers mean the cancer is more advanced. Once a persons T, N, and M categories have been determined, this information is combined in a process called stage grouping to assign an overall stage. For more information see Cancer Staging.

The staging system in the table below uses the pathologic stage . It is determined by examining tissue removed during an operation. Sometimes, if surgery is not possible right away or at all, the cancer will be given a clinical stage instead. This is based on the results of a physical exam, biopsy, and imaging tests. The clinical stage will be used to help plan treatment. Sometimes, though, the cancer has spread further than the clinical stage estimates, and might not predict the patients outlook as accurately as a pathologic stage.

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How Does Breast Cancer Spread

Breast cancer can invade and grow into the tissue surrounding your breast or it can travel to other parts of your body and form a new tumor there. Nearly all types of cancer have the ability to spread , but whether or not it will spread is often linked to what type of breast cancer you have.

Breast cancer can spread in three ways:

  • It can spread from your breast into surrounding areas .
  • Cancer cells can travel through the bloodstream to other areas of your body.
  • Cancer cells can also move through your lymphatic system to other parts of your body.

Every cancer is different, but the type of breast cancer you have typically plays a role in how aggressive or slow moving it is and where its most likely to spread, says Dr. Roesch.

Where In The Body Does Breast Cancer Spread

I Have Thyroid Cancer

In theory, breast cancer can spread to any part of your body, but it most commonly spreads to your lymph nodes, lungs, liver, bones and, sometimes, your brain. Keep in mind, though, that even if your breast cancer spreads to other areas of your body, its still considered breast cancer. For example, if breast cancer spreads to your lungs, it doesnt mean that you now have lung cancer, too.

Dr. Roesch explains how metastatic breast cancer can affect different parts of your body:

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Models Of Metastatic Progression

A model of metastatic progression in cancer. Primary tumor growth and invasion occur through the gain of genetic or epigenetic changes in the primary tumor often in cells that have a change in character through the process of epithelial to mesenchymal transition . Individual cells, or groups of cells, that have gone through this transition, as well as those that have not , gain access to blood vessels through incompletely defined mechanisms. Some of the cells are targeted to specific organs and enter their new microenvironment. Cells that have dedifferentiated are likely able to modify the premetastatic niche to allow for proliferation and invasion with short latency in the metastatic site. Cells shed into the circulation that are more differentiated likely enter a period of prolonged dormancy controlled by a number of factors that may be released over time through changes in the tumor cells or the metastatic microenvironment. In both cases, metastatic progression at the metastatic site likely requires interactions with immune cells, endothelial cells, and the stroma.

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